| 货号 | 11988-50mg |
| 描述 | Cinnabarinic acid is a phenoxazinone produced by the oxidative dimerization of 3-hydroxyanthranilic acid (3-HAA) as part of the metabolism of tryptophan in the kynurenic pathway.1,2 It acts as a partial receptor agonist of the metabotropic glutamate receptor 4 (mGlu4), effective at 100 µM, with no activity at other mGlu receptor subtypes.3 3-HAA does not affect mGlu receptors, including mGlu4. Cinnabarinic acid induces apoptosis of T cells at 300-500 µM, a potency some ten times that of 3-HAA.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Subba Rao, P.V., and Vaidyanathan, C.S. Enzymic conversion of 3-hydroxyanthranilic acid into cinnabarinic acid. Partial purification and properties of rat-liver cinnabarinate synthase. Biochemistry Journal 99(2), 317-322 (1966). 2.Stone, T.W.,Stoy, N., and Darlington, L.G. An expanding range of targets for kynurenine metabolites of tryptophan. Trends in Pharamacological Sciences 34(2), 136-143 (2013). 3.Fazio, F.,Lionetto, L.,Molinaro, G., et al. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Molecular Pharmacology 81(5), 643-656 (2012). 4.Hiramatsu, R.,Hara, T.,Akimoto, H., et al. Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. Journal of Cellular Biochemistry 103(1), 42-53 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 300.3 |
| 分子式 | C14H8N2O6 |
| CAS号 | 606-59-7 |
| 稳定性 | ≥ 1 year |
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