| 货号 | 5025/50 |
| 别名 | (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl) |
| 供应商 | Tocris |
| 生物活性 | Necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 461.47 |
| 分子式 | C18H15N5O6 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Kreuzaleret al (2012) Killing a cancer: what are the alternatives? Nat.Rev.Cancer. 12 411. PMID: 22576162. Sunet al (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148 213. PMID: 22265413. Zhouet al (2012) New components of the necroptotic pathway. Protein Cell 3 811. PMID: 23073834. |