| 货号 | 17050-1mg |
| 描述 | Helenalin is a sesquiterpene lactone first isolated from various species of Arnica. It has anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-κB at doses from 1 to 20 µM.1,2 Like other sesquiterpene lactones, helenalin can modify sulfhydryl groups of cysteine residues and it alkylates these groups on the p65 subunit of NF-κB.1 It also suppresses the proliferation of cancer cells through multiple mechanisms, including the prevention of signaling through NF-κB.3,4,5 Helenalin has antibacterial and anti-protozoal activities.6,7 |
| 别名 | NSC 85236; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lyss, G.,Knorre, A.,Schmidt, T.J., et al. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65. The Journal of Biological Chemisty 273(50), 33508-33516 (1998). 2.Jin, F.,Liu, X.,Zhou, Z., et al. Activation of nuclear factor-κB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells. Cancer Research 65(14), 6354-6363 (2005). 3.Fernandes, K.M.,Auld, C.A.,Hopkins, R.G., et al. Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyte proliferation. Journal of Cellular Biochemistry 105(3), 913-921 (2008). 4.Zhao, L.,Lee, J.Y., and Hwang, D.H. Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. Nutrition Reviews 69(6), 310-320 (2011). 5.Lim, C.B.,Fu, P.Y.,Zhu, H.S., et al. NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death. BMC Complement.Altern.Med. 12, 1-12 (2012). 6.Schmidt, T.J.,Nour, A.M.M.,Khalid, S.A., et al. Quantitative structure-antiprotozoal activity relationships of sesquiterpene lactones. Molecules 14(6), 2062-2076 (2009). 7.Boulanger, D.,Brouillette, E.,Jaspar, F., et al. Helenalin reduces Staphylococcus aureus infection in vitro and in vivo. Vet.Microbiol. 119, 330-338 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 262.3 |
| 分子式 | C15H18O4 |
| CAS号 | 6754-13-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |