| 货号 | 1610/50 |
| 别名 | 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-d |
| 供应商 | Tocris |
| 生物活性 | Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 μM respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 516.55 |
| 分子式 | C30H28O8 |
| 可溶性/溶解性 | Soluble to 2 mM in ethanol with gentle warming and to 20 mM in DMSO |
| CAS号 | 82-08-6 |
| 参考文献 | Balgiet al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124. PMID: 19771169. Zhanget al (2007) Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's disease. J.Pharmacol.Exp.Ther. 322 913. PMID: 17565007. Davieset al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. PMID: 10998351. Gschwendtet al (1994) Rottlerin, a novel protein kinase inhibitor. Biochem.Biophys.Res.Commun. 199 93. PMID: 8123051. |