| 货号 | 16921-5mg |
| 描述 | Metformin-d6 contains six deuterium atoms on the two methyl substituents. It is intended for use as an internal standard for the quantification of metformin (Item No. 13118) by GC- or LC-mass spectrometry. Metformin is an orally administered biguanide derivative used to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus.1 It improves insulin sensitivity and decreases insulin resistance by inhibiting Complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase-dependent signaling.2,3 At 50-400 mg/kg body weight, metformin can stimulate glucose uptake in skeletal muscle and suppress hepatic gluconeogenesis in B6-Lepob/obmice.2 Metformin has also been shown to improve fatty liver disease by reversing hepatic steatosis in ob/ob mice, restoring ovarian function in polycystic ovary syndrome, and directly inhibiting tumor growth in cancer cell lines.4,3 |
| 别名 | Apophage-d6;Diaformin-d6;Fornidd-d6;Glucoformin-d6;Glucophage-d6;LA 6023-d6;Melbin-d6;Orabet-d6;Riomet-d6;Walaphage-d6; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bailey, C.J., and Turner, R.C. Drug therapy: Metformin. New England Journal of Medicine 334(9), 574-579 (1996). 2.Kim, Y.D.,Park, K.G.,Lee, Y.S., et al. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 57(2), 306-314 (2008). 3.Viollet, B.,Guigas, B.,Garcia, N.S., et al. Cellular and molecular mechanisms of metformin: An overview. Clin.Sci.(Lond) 122(6), 253-270 (2012). 4.Dowling, R.J.O.,Niraula, S.,Stambolic, V., et al. Metformin in cancer: Translational challenges. Journal of Molecular Endocrinology 48(3), R31-R43 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% deuterated forms (d1-d6) |
| 计算分子量 | 171.6 |
| 分子式 | C4H5D6N5 • HCl |
| CAS号 | 1185166-01-1 |
| 稳定性 | ≥ 2 years |
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