| 货号 | 5389/50 |
| 别名 | (4-Bromophenyl)[2-fluoro-4-[[6-(met |
| 供应商 | Tocris |
| 生物活性 | 2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 564.44 |
| 分子式 | C23H27BrFNO2.C |
| 可溶性/溶解性 | Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO |
| 参考文献 | Shoemakeret al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 8 e56265. PMID: 23441171. Grinteret al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 29 795. PMID: 21315634. Morandet al (1997) Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J.Lipid.Res. 38 373. PMID: 9162756. |