Wnt Agonist I
货号：
19903-50mg 基本售价：
5250.0 元 规格：
50 mg
产品信息
概述| 货号 | 19903-50mg |
| 描述 | Wnt Agonist I is a cell-permeable activator of Wnt signaling that does not inhibit GSK-3β (IC50 > 60 µM).1 It induces nuclear accumulation of β-catenin, increasing transcriptional activity driven by TCF (EC50 = 700 nM) and altering embryonic development.1,2 Wnt Agonist I is effective in vivo, decreasing tissue damage and improving renal function after ischemia-reperfusion in rats.3 |
| 别名 | BML-284; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, J.,Wu, X.,Mitchell, B., et al. A small-molecule agonist of the Wnt signaling pathway. Agnew. Chem. Int. Ed. Engl. 44(13), 1987-1990 (2005).
2.Lim, J.C.,Kania, K.D.,Wijesuriya, H., et al. Activation of β-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J. Neurochem. 106(4), 1855-1865 (2008).
3.Kuncewitch, M.,Yang, W.-L.,Corbo, L., et al. WNT agonist decreases tissue damage and improves renal function after ischemia-reperfusion. Shock 43(3), 268-275 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 350.4 |
| 分子式 | C19H18N4O3 |
| CAS号 | 853220-52-7 |
| 稳定性 | ≥ 2 years |
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