| 货号 | 2728/10 |
| 别名 | (S)-1-(2-Amino-2-carboxyethyl)-3-(2 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective GluR5-containing kainate receptor antagonist (IC50 = 7 nM) that displays selectivity over GluR6-containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 429.45 |
| 分子式 | C20H19N3O6S |
| 可溶性/溶解性 | Soluble to 20 mM in 3eq. NaOH |
| 参考文献 | Darganet al (2009) ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function. Neuropharmacology 56 121. PMID: 18789344. Dolmanet al (2007) Synthesis and pharmacological characterisation of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. J.Med.Chem. 50 1558. PMID: 17348638. |