| 货号 | 2158/1 |
| 别名 | (1R*,2S*)-4-[2-Chloro-6-(methylamin |
| 供应商 | Tocris |
| 生物活性 | Selective, high affinity competitive antagonist of the P2Y1 receptor (Ki = 2.5 nM; IC50 = 51.6 nM). Fails to block nucleotide signaling at most other P2Y receptors (P2Y2, P2Y4, P2Y6, P2Y11 and P2Y12) and potently inhibits ADP-induced aggregation of human blood platelets in vitro(pKB = 8.05). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 503.78 |
| 分子式 | C13H18ClN5O8P2.2NH3 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 367909-40-8 |
| 参考文献 | Kimet al (2003) 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. J.Med.Chem 46 4974. PMID: 14584948. Boyeret al (2002) 2-Chloro N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y1 receptor antagonist. Br.J.Pharmacol. 135 2004. PMID: 11959804. Nandananet al (2000) Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y1 receptor ligands. J.Med.Chem. 43 829. PMID: 10715151. |