MLL1 (human recombinant)
货号：
10658-100ug 基本售价：
5040.0 元 规格：
100 ug
产品信息
概述| 货号 | 10658-100ug |
| 描述 | Mixed Lineage Leukemia (MLL1) plays a major role in epigenetic regulation through methylation of histone 3 at lysine 4 (H3K4) to activate gene transcription. Methylation of H3K4 leads to upregulation of developmental genes, including HOX family members.1 In addition to its methylation activity, MLL1 has been shown to co-localize with Pol II at several genomic elements.2 Consequently, MLL1 has very low basal methyltransferase activity unless complexed with the activating protein complex of WDR5, Ash2L, and RbBP5 (MLL/WAR complex).3 This C-terminal fragment of MLL1, residues 3762 - 3969, contains the SET1 domain for methyltransferase activity, and the WIN motif for binding the WAR complex. The protein DPY-30 has also been reported to associate with the MLL1-WAR complex. MLL1 is also available as a component of the MLL1/WAR complex (Item No. 10756) and MLL1/WARD complex (Item No. 10945). |
| 别名 | ALL1;CXXC-type zinc finger protein 7;HRX;KMT2a;Lysine Methyltransferase 2A;Mixed Lineage Leukemia 1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Patel, A.,Dharmarajan, V.,Vought, V.E., et al. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. The Journal of Biological Chemisty 284(36), 24242-24256 (2009).
2.Mohan, M.,Lin, C.,Guest, E., et al. Licensed to elongate: A molecular mechanism for MLL-based leukaemogenesis. Nature Reviews.Cancer 10(10), 721-728 (2010).
3.Smith, E.,Lin, C. and Shilatifard, A. The super elongation complex (SEC) and MLL in development and disease. Genes & Development 25(7), 661-672 (2011).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
