| 货号 | 13964-5mg |
| 描述 | The protein kinase C (PKC) isoforms PKCβ1 and PKCβ2 have central roles in cell signaling in diabetes, diffuse large B-cell lymphoma, and cardiovascular diseases.1,2,3,4 LY333531 is a selective and potent inhibitor of PKCβ1 and PKCβ2 (IC50 = 4.7 and 5.9 nM, respectively).5 For comparison, its IC50 values for PKC isoforms α, γ, δ, ε, ζ, and η are 360, 300, 250, 600, >100,000, and 52 nM, respectively.5 LY333531 is effective in vivo.1,2 |
| 别名 | Ruboxistaurin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Geraldes, P. and King, G.L. Activation of protein kinase C isoforms and its impact on diabetic complications. Circulation Research 106, 1319-1331 (2010). 2.Ferreira, J.C.B.,Brum, P.C. and Mochly-Rosen, D. βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure. Journal of Molecular and Cellular Cardiology 51(4), 479-484 (2011). 3.Friedberg, J.W. New strategies in diffuse large B-cell lymphoma: Translating findings from gene expression analyses into clinical practice. Clinical Cancer Research 17(19), 6112-6117 (2011). 4.Tesch, G.H. and Lim, A.K.H. Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy. American Journal of Physiology.Renal Physiology 300, F301-F310 (2011). 5.Jirousek, M.R.,Gillig, J.R.,Gonzalez, C.M., et al. (S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase Cβ. Journal of Medicinal Chemistry 39, 2664-2671 (1996). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 505 |
| 分子式 | C28H28N4O3 • HCl |
| CAS号 | 169939-93-9 |
| 稳定性 | ≥ 2 years |
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