| 货号 | 11348-5mg |
| 描述 | (S)-Ketorolac is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID; IC50s = 0.1 and 2.7 µM for COX-1 and COX-2, respectively).1 (S)-Ketorolac is approximately twice as potent as the racemic mixture (Item No. 9001148) and 60 times more potent than (R)-ketorolac in a rat pain assay.2 (S)-Ketorolac is cleared from rat kidney and liver more quickly than (R)-ketorolac.3 Formulations containing ketorolac are used to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation.4 |
| 别名 | (-)-Ketorolac; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Handley, D.A.,Cervoni, P.,McCray, J.E., et al. Preclinical enantioselective pharmacology of (R)- and (S)- ketorolac. J. Clin. Pharmacol. 38, 25S-35S (1998). 2.Guzmán, A.,Yuste, F.,Toscano, R.A., et al. Absolute configuration of (−)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac. J. Med. Chem. 29(4), 589-591 (1986). 3.Dubey, S.K.,Anand, A. and Saha, R.N. Enantioselective tissue distribution of ketorolac and its enantiomers in rats. Drug Res. (Stuttg.) 65(8), 428-431 (2015). 4.Gordon, S.M.,Brahim, J.S.,Rowan, J., et al. Pharmacodynamics and drug action. Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: Replicate clinical trials in a tissue injury model. Clin. Pharmacol. Ther. 72(2), 175-183 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 255.3 |
| 分子式 | C15H13NO3 |
| CAS号 | 66635-92-5 |
| 稳定性 | ≥ 2 years |
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