| 货号 | 19057-50g |
| 描述 | Sodium oxamate is a derivative of pyruvate that inhibits the conversion of pyruvate to lactate via lactate dehydrogenase, thus disrupting glycolysis.1 Because cancer cells produce a large amount of energy via aerobic glycolysis, sodium oxamate has been studied as an inhibitor of carbohydrate metabolism in various tumors.2,3,4,5 |
| 别名 | Oxalic Acid monoamide;Oxamic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Novoa, W.B.,Winer, A.D.,Glaid, A.J., et al. Lactic dehydrogenase. V. Inhibition by oxamate and by oxalate. The Journal of Biological Chemisty 234(5), 1143-1148 (1959). 2.Yang, Y.,Su, D.,Zhao, L., et al. Different effects of LDH-A inhibition by oxamate in non-small cell lung cancer cells. Oncotarget 5(23), 11886-11896 (2014). 3.Zub, K.A.,de Sousa, M.M.L.,Sarno, A., et al. Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells. PLoS One 10(3), (2015). 4.Cui, J.,Shi, M.,Xie, D., et al. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clinical Cancer Research 20(10), 2595-2606 (2014). 5.Zhao, Z.,Han, F.,Yang, S., et al. Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway. Cancer Letters 358(1), 17-26 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% |
| 计算分子量 | 111 |
| 分子式 | C2H2NO3 • Na |
| CAS号 | 565-73-1 |
| 稳定性 | ≥ 2 years |
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