| 货号 | 2250/1 |
| 别名 | 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mann |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 516.46 |
| 分子式 | C25H24O12 |
| 可溶性/溶解性 | Soluble to 20 mM in ethanol and to 10 mM in DMSO |
| CAS号 | 77307-50-7 |
| 参考文献 | Bainet al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297. PMID: 17850214. Godeny and Sayeski (2006) ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. Am.J.Cell.Physiol. 2911308. Smithet al (2005) Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 65 1027. PMID: 15705904. |