SR 9011
货号：
11930-5mg 基本售价：
4410.0 元 规格：
5 mg
产品信息
概述| 货号 | 11930-5mg |
| 描述 | SR 9011 is a REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERBα and REV-ERBβ with IC50 values of 790 and 560 nM, respectively.1 It has no activity at other nuclear receptors. SR 9011 blocks the activity of the suprachiasmatic nucleus (SCN) clock, with reversible inhibition of circadian oscillation in SCN explants cultured from Per2-luc reporter mice.1 The circadian pattern of expression of several metabolic genes in liver, skeletal muscle, and adipose tissue was also shown to be altered in mice exposed to SR 9011, resulting in increased energy expenditure.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Solt, L.A.,Wang, Y.,Banerjee, S., et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485, 62-68 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 479 |
| 分子式 | C23H31ClN4O3S |
| CAS号 | 1379686-29-9 |
| 稳定性 | ≥ 2 years |
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