Resolvin D2-d5
货号：
11184-25ug 基本售价：
4354.0 元 规格：
25 ug
产品信息
概述| 货号 | 11184-25ug |
| 描述 | RvD2-d5 contains five deuterium atoms at the 21, 21’, 22, 22, and 22 positions. It is intended for use as an internal standard for the quantification of RvD2 by GC- or LC-mass spectrometry (MS). Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2 Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.3 It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.3 Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.3 |
| 别名 | 7(S),16(R),17(S)-Resolvin D2-d5;RvD2-d5; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hong, S.,Gronert, K.,Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. The Journal of Biological Chemisty 278(17), 14677-14687 (2003).
2.Ariel, A. and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. TRENDS in Immunology 28(4), 176-183 (2007).
3.Spite, M.,Norling, L.V.,Summers, L., et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 461(7268), 1287-1291 (2009).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 计算分子量 | 381.5 |
| 分子式 | C22H27D5O5 |
| CAS号 | 1881277-33-3 |
| 稳定性 | ≥ 1 year |
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