| 货号 | 4926/10 |
| 别名 | (1S,2S)-2-(3,4-Dichlorobenzoyl)cycl |
| 供应商 | Tocris |
| 生物活性 | Potent kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (IC50 = 20 nM). Increases kynurenic acid levels, and decreases 3-HK and QUIN levels in cerebrum and liver of neonatal rodents. Neuroprotective in a Drosophila model of Huntington's disease. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 259.09 |
| 分子式 | C11H8Cl2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol |
| 参考文献 | Amaralet al (2013) Structural basis of kynurenine 3-monooxygenase inhibition. Nature 496 382. PMID: 23575632. Campesanet al (2011) The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease. Curr.Biol. 21 961. PMID: 21636279. Amoriet al (2009) On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J.Neurochem. 109 316. PMID: 19226371. Ceresoli-Borroniet al (2007) Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J.Neurosci.Res. 85 845. PMID: 17279543. |