| 货号 | 5429/5 |
| 别名 | N-[4-[(4-Ethyl-1-piperazinyl)methyl |
| 供应商 | Tocris |
| 生物活性 | TGF-β-activated kinase (TAK1) inhibitor (IC50 = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC50 values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-α and TLR7/8 agonist CL097-stimulated secretion of IFN-β in Gen 2.2 leukemia cells in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 537.58 |
| 分子式 | C29H30F3N5 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Tanet al (2015) Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J.Med.Chem. 58 183. PMID: 25075558. Dzamkoet al (2012) The IkappaB kinase family phosphorylates the Parkinsons disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. PLoS ONE 7 e39132. PMID: 22723946. Paulset al (2012) Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells. J.Biol.Chem. 287 19216. PMID: 22511786. |