| 货号 | 3905/10 |
| 别名 | Nicotinic acid adenine dinucleotide phosphate tetrasodium salt; NAADP |
| 供应商 | Tocris |
| 生物活性 | Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 832.32 |
| 分子式 | C21H23N6Na4O18P3 |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| CAS号 | 5502-96-5 |
| 参考文献 | Calcraftet al (2009) NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 459 596. PMID: 19387438. Dammermanet al (2009) NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist. Proc.Natl.Acad.Sci. 10610678. Galion (2006) NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores. Biochem.Soc.Transactions 34922. |