| 货号 | 1443/100U |
| 供应商 | Tocris |
| 生物活性 | Potent endogenous ligand of the kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.80 and 1.45 nM respectively. Inhibits chemotaxis, invasion and metastasis of human melanomas and breast carcinomas. Stimulates gonadotropin secretion following i.c.v. administration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 5857.49 |
| 分子式 | C258H401N79O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | GTSLSPPPESSGSRQQPGLSAPHSRQIPAP (Modifications: Phe-54 = C-terminal amide) |
| 参考文献 | Gottschet al (2004) A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145 4073. PMID: 15217982. Kotaniet al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631. PMID: 11457843. Ohtakiet al (2001) Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411 613. PMID: 11385580. |