| 货号 | 2267/200U |
| 别名 | (2R,3S,4R)-3-Hydroxy-2-[(1S)-1-hydr |
| 供应商 | Tocris |
| 生物活性 | A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 376.42 |
| 分子式 | C15H24N2O7 |
| 可溶性/溶解性 | Soluble to 10 mM in water |
| 参考文献 | Bellaset al (1997) Inhibition of NF-κB activity induces apoptosis in murine hepatocytes. Am.J.Pathol. 151 891. PMID: 9327720. Fenteanyet al (1995) Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268 726. PMID: 7732382. Omuraet al (1991) Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J.Antibiot. 44 113. PMID: 1848215. |