| 货号 | 2641/10 |
| 别名 | (2S)-2-Amino-N-[(1S,2S,4R)-7,7-dime |
| 供应商 | Tocris |
| 生物活性 | Potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). Antagonizes oxytocin-induced uterine contractions in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 591.23 |
| 分子式 | C26H42N4O5S2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 148927-60-0 |
| 参考文献 | Borthwick (2010) Oral oxytocin antagonists. J.Med.Chem. 53 6525. PMID: 20550119. Quattropaniet al (2005) Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonist. J.Med.Chem. 48 7882. PMID: 16302826. Mannet al (2003) Attenuation of PGE2α release in ewes infused with the oxytocin antagonist L-368,899. Domest.Anim.Endocrinol. 25 255. PMID: 14550509. Williamset al (1994) 1-(((7,7-dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine (L-368,899): an orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm labor. J.Med.Chem. 37 565. PMID: 8126695. |