| 货号 | 2216/1 |
| 供应商 | Tocris |
| 生物活性 | Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3358.68 |
| 分子式 | C148H221N41O47S |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 110084-95-2 |
| 序列号 | SQGTFTSEYSKYLDSRRAQDFVQWLMNT (Modifications: Thr-28 = C-terminal amide) |
| 参考文献 | Huypenset al (2000) Glucagon receptors on human islet cells contribute to glucose competence of insulin release. Diabetologia 43 1012. PMID: 10990079. Unsonet al (1989) Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides 10 1171. PMID: 2560175. Unsonet al (1987) Synthetic peptide antagonists of glucagon. Proc.Natl.Acad.Sci.USA 844083. |