| 货号 | 4123/1 |
| 供应商 | Tocris |
| 生物活性 | Transferase-deficient neurotrophic fragment of clostridial C3 protein. Promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations. Also promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. Reduces levels of active neuronal RhoA by a non-enzymatic mechanism. Enhances functional recovery and regeneration in a mouse model of spinal cord injury. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3058.54 |
| 分子式 | C137H221N37O |
| 可溶性/溶解性 | Soluble to 5 mg/ml in water |
| 序列号 | VAKGSKAGYIDPISAFAGQLEMLLPRHST |
| 参考文献 | Justet al (2011) Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn-Schmied.Arch.Pharmacol. 383247. Boatoet al (2010) C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts. J.Cell Science 1231652. Holtjeet al (2009) A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation. FASEB J. 23 1115. PMID: 19047066. |