| 货号 | 4561/10 |
| 别名 | 1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective CGRP receptor antagonist (IC50 values are 0.03 and 6.4 nM for human and rat CGRP receptors respectively). Displays high affinity for human CGRP receptors (Ki = 14.4 pM); exhibits no significant affinity for 75 other receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 869.65 |
| 分子式 | C38H47Br2N9< |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 50 mM in 2eq.HCl |
| 参考文献 | Rudolfet al (2005) Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1- piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)piperazine: the first CGRP antagonist for clinical trials in acute migraine. J.Med.Chem. 48 5921. PMID: 16161996. Doodset al (2000) Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br.J.Pharmacol. 129 420. PMID: 10711339. |