| 货号 | 1652/1 |
| 供应商 | Tocris |
| 生物活性 | Prototypical potent and highly selective inhibitor of the small-conductance Ca2+-activated K+-channel (KCa2, SK). Blocks medium after-hyperpolarization in vitro and is brain penetrant and convulsive in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2027.34 |
| 分子式 | C79H131N31O24S4 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 24345-16-2 |
| 序列号 | CNCKAPETALCARRCQQH (Modifications: Disulfide bridge between 1 - 11, 3 - 15, His-18 = C-terminal amide) |
| 参考文献 | Stockeret al (2004) Matching molecules to function: neuronal Ca2+-activated K+ channels and afterhyperpolarizations. Toxicon 43 933. PMID: 15208027. van der Staayet al (1999) Behavioral effects of apamin, a selective inhibitor of the SKCa-channel, in mice and rats. Neurosci.Biobehav.Rev. 23 1087. PMID: 10643819. Strong (1990) Potassium channel toxins. Pharmacol.Ther. 46 137. PMID: 2181489. Habermann (1984) Apamin. Pharmacol.Ther. 25 255. PMID: 6095335. |