HNHA
货号：
13295-25mg 基本售价：
4284.0 元 规格：
25 mg
产品信息
概述| 货号 | 13295-25mg |
| 描述 | HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC50 = 100 nM).1 In human fibrosarcoma HT1080 cells, it induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC50 ~ 7.5 μM).1 HNHA is at least as effective as SAHA in inhibiting tumor growth in a murine xenograph model in vivo.1 HNHA also blocks the growth of human umbilical vein endothelial cells (HUVECs) and prevents tube formation and migration of HUVECs in response to vascular endothelial growth factor (VEGF). It also blocks retinal neovascularization and choroidal angiogenesis in mice.2 |
| 别名 | Histone Deacetylase Inhibitor VI; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kim, D.H.,Lee, J.,Kim, K.N., et al. Anti-tumor activity of N-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor. Biochemical and Biophysical Research Communications 356, 233-238 (2007).
2.Kim, J.H.,Kim, J.H.,Oh, M., et al. N-hydroxy-7-(2-naphthylthio) heptanomide inhibits retinal and choroidal angiogenesis. Molecular Pharmaceutics 6(2), 513-519 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 303.4 |
| 分子式 | C17H21NO2S |
| CAS号 | 926908-04-5 |
| 稳定性 | ≥ 2 years |
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