Malformin C
货号：
21613-1mg 基本售价：
4270.0 元 规格：
1 mg
产品信息
概述| 货号 | 21613-1mg |
| 描述 | Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus.1 Malformin C potently blocks the ability of bleomycin (Item No. 13877) to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM).2 It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM).2 Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 µM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.3 |
| 别名 | Malformin B1b; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kobbe, B.,Cushman, M.,Wogan, G.N., et al. Production and antibacterial activity of malforming C, a toxic metabolite of Aspergillus niger. Appl. Environ. Microbiol. 33(4), 996-997 (1977).
2.Hagimori, K.,Fukuda, T.,Hasegawa, Y., et al. Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells. Biol. Pharm. Bull. 30(8), 1379-1383 (2007).
3.Wang, J.,Jiang, Z.,Lam, W., et al. Study of malformin C, a fungal source cyclic pentapeptide, as an anti-cancer drug. PLoS One 10(11), e0140069 (2015).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 529.7 |
| 分子式 | C23H39N5O5S2 |
| CAS号 | 59926-78-2 |
| 稳定性 | ≥ 3 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
