| 货号 | 11339-1mg |
| 描述 | K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C.1 However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture.2,3 K252b inhibits receptor-mediated degranulation from basophil-like RBL-2H3 cells (IC50 = 0.5 μg/ml) and human basophils.4 This extracellular inhibitor is also used in comparison studies with the closely related, cell-permeable inhibitor K252a, particularly in studies of neuronal differentiation.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yasuzawa, T.,Iida, T.,Yoshida, M., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d. Journal of Antibiotics 39(8), 1072-1078 (1986). 2.Plomp, J.J., and Molenaar, P.C. Involvement of protein kinases in the upregulation of acetylcholine release at endplates of α-bungarotoxin-treated rats. Journal of Physiology 493, 175-186 (1996). 3.Zhu, X.,Luo, C.,Ferrier, J.M., et al. Evidence of ectokinase-mediated phosphorylation of osteopontin and bone sialoprotein by osteoblasts during bone formation in vitro. Biochemistry Journal 323, 637-643 (1997). 4.Teshima, R.,Saito, Y.,Ikebuchi, H., et al. Effect of an ectokinase inhibitor, K252b, on degranulation and Ca2+ signals of RBL-2H3 cells and human basophils. Journal of Immunology 159(2), 964-969 (1997). 5.Thompson, A.F., and Levin, L.A. Neuronal differentiation by analogs of staurosporine. Neurochemistry International 56(4), 554-560 (2010). 6.Kawamura, N.,Kawamura, K.,Manabe, M., et al. Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth. Endocrinology 151(7), 3006-3014 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 453.5 |
| 分子式 | C26H19N3O5 |
| CAS号 | 99570-78-2 |
| 稳定性 | ≥ 2 years |
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