| 货号 | 2761/50 |
| 别名 | DL-2-(Difluoromethyl)-ornithine hydrochloride; Eflornithine |
| 供应商 | Tocris |
| 生物活性 | Irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 218.63 |
| 分子式 | C6H12F2N2O2.HCl |
| 可溶性/溶解性 | Soluble to 75 mM in water |
| CAS号 | 70052-12-9 |
| 参考文献 | Wuet al (2012) Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. Biochem.J. 442 693. PMID: 22132744. Raul (2007) Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent. Biochem.Soc.Trans. 35 353. PMID: 17371277. Carrilloet al (2000) Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase. Biochem.Biophys.Res.Comm. 279663. |