| 货号 | 10946-50ug |
| 描述 | ASH2L is the human homolog of the Drosophila absent, small or homeotic discs 2 (ash2) gene product, a member of the trithorax group (TrxG) of proteins.1 The TrxG gene products in Drosophila and their mammalian homologs are responsible for controlling gene transcription. The ASH2L protein is a component of various multisubunit protein complexes, including the large complex of proteins associated with the SET1 (MLL) family of lysine methyltransferases.2 ASH2L, along with WDR5 and RbBP5, form the human MLL1 core protein complex.3 MLL1-5 protein complexes catalyze the di- and trimethylation of histone H3 at lysine 4 (H3K4me2/me3), leading to the maintenance of global H3K4 trimethylation.4 Post-translational modifications of ASH2L have also been described showing methylation of Arg-296 by protein-arginine methyltransferease 1 (PRMT1) in vitro and in cells and by PRMT5 in vitro.5 Further experimental evidence in rats suggests that ASH2L cooperates with Ha-RAS to transform rat embryonic fibroblasts, implicating ASH2L as a novel oncoprotein.6 |
| 别名 | Absent, small, or homeotic discs 2-like;Set1/Ash2 Histone Methyltransferase Complex Subunit Ash2 Isoform A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wang, J.,Zhou, Y.,Yin, B., et al. ASH2L: Alternative splicing and downregulation during induced megakaryocytic differentiation of multipotential leukemia cell lines. Journal of Molecular Medicine 79(7), 399-405 (2001). 2.Steward, M.M.,Lee, J.S.,ODonovan, A., et al. Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes. Nature Structural & Molecular Biology 13(9), 852-854 (2009). 3.Dou, Y.,Milne, T.A.,Ruthenburg, A.J., et al. Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nature Structural & Molecular Biology 13(8), 713-719 (2006). 4.Wang, P.,Lin, C.,Smith, E.R., et al. Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Molecular and Cellular Biology 29(22), 6074-6085 (2009). 5.Butler, J.S.,Zurita-Lopez, C.,Clarke, S.G., et al. Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. The Journal of Biological Chemisty 286(14), 12234-12244 (2011). 6.Lüscher-Firzlaff, J.,Gawlista, I.,Vervoorts, J., et al. The human trithorax protein hASH2 functions as an oncoprotein. Cancer Research 68(3), 749-758 (2008). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥90% |
| 稳定性 | ≥ 6 months |
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