| 货号 | 2675/10 |
| 别名 | N-[[[(1S)-1-Carboxy-3-methylbutyl]a |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM) . Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 304.3 |
| 分子式 | C12H20N2O7 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 723331-20-2 |
| 参考文献 | Yamamotoet al (2007) Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. Eur.J.Neurosci. 25 147. PMID: 17241276. Zhouet al (2005) NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat.Rev.Drug Discov. 4 1015. PMID: 16341066. Olszewskiet al (2004) NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J.Neurochem. 89 876. PMID: 15140187. |