| 货号 | 4664/100U |
| 供应商 | Tocris |
| 生物活性 | Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1overα2β1,αIIbβ3,αvβ3,α4β1,α5β6,α9β1andα4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4393.07 |
| 分子式 | C184H284N52O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | CTTGPCCRQCKLKPAGTTCWKTSLTSHYCT (Modifications: Disulfide bridge: 1 - 10, 6 - 29, 7 - 34, 19 - 36) |
| 参考文献 | Brownet al (2008) Angiostatic activity of obtustatin as α1β1 integrin inhibitor in experimental melanoma growth. Int.J.Cancer 123 2195. PMID: 18712720. Marcinkiewiczet al (2003) Obtustatin: a potent and selective inhibitor of α1β1 integrin in vitro and angiogenesis in vivo. Cancer Res. 63 2020. PMID: 12727812. Moreno-Murcianoet al (2003) Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa. Protein Sci. 12 366. PMID: 12538900. |