| 货号 | 3914/10 |
| 别名 | 7-[trans-4-(4-Methyl-1-piperazinyl) |
| 供应商 | Tocris |
| 生物活性 | Potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 592.01 |
| 分子式 | C29H34N6O.3HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Saitoet al (2013) A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci.Transl.Med. 5. PMID: 23596204. Pene-Dumitrescuet al (2008) An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad spectrum Src family kinase inhibitor A-419259. Oncogene 27 7055. PMID: 18794796. Wilsonet al (2002) Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene 21 8075. PMID: 12444544. |