TCS ERK 11e (10 MG)
货号：
4465/10 基本售价：
3797.2 元 规格：
10 mg
产品信息
概述| 货号 | 4465/10 |
| 别名 | 4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide; VX 11e |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 500.35 |
| 分子式 | C24H20Cl2FN5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Aronovet al (2009) Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-related kinase (ERK) using conformational control. J.Med.Chem. 52 6362. PMID: 19827834. |
