| 货号 | 3220/100U |
| 供应商 | Tocris |
| 生物活性 | Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro(IC50 < 500 pM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4012.7 |
| 分子式 | C166H268N54O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | RSCIDTIPKSRCTAFQCKHSMXYRLSFCRK (Modifications: Disulfide bridges: 3-35,12-28,17-32), X= Dap) |
| 参考文献 | Robbinset al (2005) Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via KV1.3 channels. J.Physiol. 564 131. PMID: 15677684. Kalmanet al (1998) ShK-Dap22, a potent KV1.3-specific immunosuppresive polypeptide. J.Biol.Chem. 273 32697. PMID: 9830012. |