15-deoxy-Δ12,14-Prostaglandin J2-d4
货号：
318570-100ug 基本售价：
3780.0 元 规格：
100 ug
产品信息
概述| 货号 | 318570-100ug |
| 描述 | 15-deoxy-Δ12,14-PGJ2-d4 contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2 by GC- or LC-mass spectrometry. 15-deoxy-Δ12,14-Prostaglandin J2(15-deoxy-Δ12,14-PGJ2) is a metabolite of PGJ2. 15-deoxy-Δ12,14-PGJ2 is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 of 2 µM in a murine chimera system.1,215-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1 |
| 别名 | 15-deoxy-Δ12,14-PGJ2-d4; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Forman, B.M.,Tontonoz, P.,Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812 (1995).
2.Kliewer, S.A.,Lenhard, J.M.,Willson, T.M., et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83, 813-819 (1995).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 320.5 |
| 分子式 | C20H24D4O3 |
| CAS号 | 1542166-82-4 |
| 稳定性 | ≥ 1 year |
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