Tephrosin (synthetic)
货号：
19840-1mg 基本售价：
3752.0 元 规格：
1 mg
产品信息
概述| 货号 | 19840-1mg |
| 描述 | Tephrosin is a rotenoid first isolated from the leaves and seeds of T. purpureaandT. vogelii that exhibits antineoplastic and piscicidal activities. The toxic actions of this compound are attributed to its ability to inhibit the NADH:ubiquinone oxidoreductase with an IC50 value of 98nM.1 Tephrosin is also reported to induce ornithine decarboxylase activity with an IC50 value of 147 nM.1 Tephrosin has been shown to enhance the cytotoxic activity of 2-deoxy-D-glucose (Item No. 14325) against various cancer human cancer cell lines, depleting intracellular ATP and inducing apoptosis.2 |
| 别名 | Deguelinol I;Hydroxydeguelin; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fang, N., and Casida, J.E. Anticancer action of cubé insecticide: Correlation for rotenoid constituents between inhibition of NADH: Ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proceedings of the National Academy of Sciences of the United States of America 95, 3380-3384 (1998).
2.Choi, Y., and Lee, J.H. The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells. Cancer Biol.Ther. 12(11), 989-996 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 410.4 |
| 分子式 | C23H22O7 |
| CAS号 | 76-80-2 |
| 稳定性 | ≥ 2 years |
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