| 货号 | 15378-500ug |
| 描述 | The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Siomycin A is a peptide thiazole antibiotic, first isolated from S. sioyaensis, that interacts with the 23S rRNA of bacteria.1 It inhibits FoxM1 (IC50 = ~5 μM), preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself.2,3 Through this mechanism, siomycin A prevents proliferation and induces apoptosis in certain types of stem cells as well as cancer cells.4,5,6 |
| 别名 | NSC 285116; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tori, K.,Tokura, K.,Yoshimura, Y., et al. 1H NMR spectral evidence for the structure and conformation of peptide antibiotic siomycin-A. J.Antibiot.(Tokyo) 32(10), 1072-1077 (1979). 2.Radhakrishnan, S.K.,Bhat, U.G.,Hughes, D.E., et al. Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1. Cancer Research 66(19), 9731-9735 (2006). 3.Gartel, A.L. Thiazole antibiotics siomycin A and thiostrepton inhibit the transcriptional activity of FOXM1. Front.Oncol. 3, 150 (2013). 4.Nakano, I.,Joshi, K.,Visnyei, K., et al. Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. Neuro.Oncol. 13(6), 622-634 (2011). 5.Joshi, K.,Banasavadi-Siddegowda, Y.,Mo, X., et al. MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells 31(6), 1051-1063 (2013). 6.Bhat, U.G.,Halasi, M. and Gartel, A.L. Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells. PLoS One 4(5), e5592 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1648.9 |
| 分子式 | C71H81N19O18S5 |
| CAS号 | 12656-09-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |