| 货号 | 1343/10 |
| 别名 | (6aR,10aR)-3-(1,1-Dimethylbutyl)-6a |
| 供应商 | Tocris |
| 生物活性 | Potent CB2 selective agonist (Ki = 3.4 nM). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis. Activity also enhances the release of IL-10 by LPS/IFN-γ-stimulated macrophages and results in downregulation of the IL-12 subunit p40. Also available in water soluble emulsion (Cat. No. 1783). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 312.49 |
| 分子式 | C22H32O |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 50 mM in DMSO with gentle warming |
| 参考文献 | Correaet al (2005) Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. Br.J.Pharmacol. 145 441. PMID: 15821753. Bakeret al (2000) Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature 404 84. PMID: 10716447. Huffmanet al (1999) 3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg.Med.Chem. 7 2905. PMID: 10658595. Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635. PMID: 10469884. |