| 货号 | 2475/10 |
| 别名 | 5-((7-Benzyloxyquinazolin-4-yl)amin |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. Selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM). Inhibits VEGF-A-induced endothelial cell proliferation in vitro(IC50 = 8 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 411.86 |
| 分子式 | C22H18FN3O2.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 324077-30-7 |
| 参考文献 | Endoet al (2003) Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF. J.Recept.Signal Transduct.Res. 23 239. PMID: 14626450. Whittleset al (2002) ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity. Microcirculation 9 513. PMID: 12483548. |