| 货号 | 1459/10 |
| 别名 | 3-[[4-(dimethylamino)phenyl]methyle |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Selective over EGFR and c-Src tyrosine kinases. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 264.33 |
| 分子式 | C17H16N2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 5812-07-7 |
| 参考文献 | Kendallet al (1999) Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J.Biol.Chem. 274 6453. PMID: 10037737. Sunet al (1998) Synthesis and biological evaluations of 3-substituted indol-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J.Med.Chem. 41 2588. PMID: 9651163. Zamanet al (1998) Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases. Biochem.Pharmacol. 57 57. PMID: 9920285. |