| 货号 | 1407/10 |
| 别名 | 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3 |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT(IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM). Negative control PP 3 (Cat. No. 2794) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 301.78 |
| 分子式 | C15H16ClN5 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming |
| CAS号 | 172889-27-9 |
| 参考文献 | Bainet al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199. PMID: 12534346. Sannaet al (2000) A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus. Proc.Natl.Acad.Sci.U.S.A. 97 8653. PMID: 10890901. Lawrence and Niu (1998) Protein kinase inhibitors: the tyrosine-specific protein kinases. Pharmacol.Ther. 77 81. PMID: 9578319. Hankeet al (1996) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. J.Biol.Chem. 271 695. PMID: 8557675. |