| 货号 | 1397/10 |
| 别名 | 1-(1,1-Dimethylethyl)-1-(4-methylph |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT(IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 281.36 |
| 分子式 | C16H19N5 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 172889-26-8 |
| 参考文献 | Bainet al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199. PMID: 12534346. Tattonet al (2003) The src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases. J.Biol.Chem. 278 4847. PMID: 12475982. Carlomagnoet al (2002) The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes. Cancer Res. 62 1077. PMID: 11861385. Liuet al (1999) Structural basis for selective inhibition of Src family kinases by PP1. Chem.Biol. 6 671. PMID: 10467133. Hankeet al (1996) Discovery of a novel, potent, and src family-selective tyrosine kinase inhibitor. J.Biol.Chem. 271 695. PMID: 8557675. |