| 货号 | 1838/10 |
| 别名 | N-3-[1,1'-Biphenyl]-4-yl-N-(3,5-dime |
| 供应商 | Tocris |
| 生物活性 | Potent endothelin receptor antagonist; shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively). Inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 573.69 |
| 分子式 | C36H35N3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH |
| CAS号 | 169545-27-1 |
| 参考文献 | Leunget al (2002) Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role of endothelin ETB receptors. J.Cardiovasc.Pharmacol. 39 533. PMID: 11904527. Balwierczaket al (1995) Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500. J.Cardiovasc.Pharmacol. 26 S393. PMID: 8587424. Webbet al (1995) Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously hypertensive and Wistar-Kyoto rats. J.Cardiovasc.Pharmacol. 26 S389. PMID: 8587423. |