| 货号 | 2474/10 |
| 别名 | 3-[3-[[[2-Chloro-3-(trifluoromethyl |
| 供应商 | Tocris |
| 生物活性 | Selective, orally active non-steroidal agonist for the liver X receptor (LXR). In cell-based reporter gene assays, acts as a full agonist of hLXRα and hLXRβ(EC50 values are 190 and 30 nM respectively). Reduces angiotensin II-mediated increases in blood pressure; up-regulates ABCA1 gene expression and raises circulating HDL levels. Displays potent antiatherogenic activity in mouse models of atherosclerosis. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 618.51 |
| 分子式 | C33H31NO3ClF3.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| CAS号 | 405911-09-3 |
| 参考文献 | Leiket al (2007) GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats. Br.J.Pharmacol. 151 450. PMID: 17420776. Collinset al (2002) Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J.Med.Chem. 45 1963. PMID: 11985463. Josephet al (2002) Synthetic LXR ligand inhibits the development of atherosclerosis in mice Proc.Natl.Acad.Sci.USA 997604. |