| 货号 | 3515/1 |
| 别名 | Cyclo[(2Z)-2-amino-2-butenoyl-L-val |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of class I histone deacetylases (HDACs) (IC50 values are 36, 47, 510 and 14,000 nM for HDAC1, HDAC2, HDAC4 and HDAC6 respectively). Exhibits cytotoxicity against various human tumor cell lines; also exhibits antitumor activity against human tumor xenografts. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 540.7 |
| 分子式 | C24H36N4O6 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Matsubaraet al (2009) Involvement of extracellular signal-regulated kinase activation in human osteosarcoma cell resistance to the histone deacetylase inhibitor FK228 [(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone]. J.Pharmacol.Exp.Ther. 328 839. PMID: 19073909. Sasakawaet al (2003) Effects of FK228, a novel histone deacetylase inhibitor, on tumor growth and expression of p21 and c-myc genes in vivo. Cancer Lett. 195 161. PMID: 12767524. Furumaiet al (2002) FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res. 62 4916. PMID: 12208741. |