| 货号 | 3920/10 |
| 别名 | 2-[[(2S)-2-Amino-3-phenylpropyl]ami |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of p38α(Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα(IC50 = 3 nM). Efficacious in acute and chronic models of arthritis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 461.56 |
| 分子式 | C29H27N5O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Dominguezet al (2005) p38 MAP kinase inhibitors: many are made, but few are chosen. Curr.Opin.Drug Discov.Devel. 8 421. PMID: 16022178. Lee and Dominguez (2005) MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr.Med.Chem. 12 2979. PMID: 16378500. |