| 货号 | 1224/50 |
| 别名 | 2-Aminoethoxydiphenylborane |
| 供应商 | Tocris |
| 生物活性 | A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 225.1 |
| 分子式 | C14H16BNO |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming |
| CAS号 | 524-95-8 |
| 参考文献 | Varnaiet al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPs 30 118. PMID: 19187978. Togashiet al (2008) Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br.J.Pharmacol. 153 1324. PMID: 18204483. Baiet al (2006) Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB). J.Pharmacol.Exp.Ther. 319 1452. PMID: 16985167. Xuet al (2005) Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltafe-dependent effect. Br.J.Pharmacol. 145 405. PMID: 15806115. Maruyamaet al (1997) 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release. J.Biochem. 122 498. PMID: 9348075. |