| 货号 | 5945/359U |
| 别名 | 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt |
| 供应商 | Tocris |
| 生物活性 | Endogenous high affinity STING agonist (Kd values are 3.79 and 120 nM for human and rat STING, respectively). Induces repolarization of M2 macrophages in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 718.37 |
| 分子式 | C20H24N10Na2 |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| 参考文献 | Zhanget al (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci.Rep. 5 18035. PMID: 26669264. Downeyet al (2014) DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization. PLoS One 9 e99988. PMID: 24940883. Zhanget al (2013) Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol.Cell. 51 226. PMID: 23747010. |